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Glutathione S-transferases (GSTs) are the enzymes expressed in the cytosol, microsomes, and mitochondria and catalyze glutathione conjugation to electrophilic compounds, not only produced from exogenous xenobiotics by biotransformation but also arise from endogenous substances

Many intrinsic and extrinsic factors, such as neurotrophic factors, transcription factors, cell cycle regulators, cell proliferation, neurogenic niche and differentiation into mature neurons, play an important role in the pathomechanism of AD